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Ndt1/Ndt2 double deletion mutants showed decreased mitochondrial and cellular NAD(H) levels and increased chronological lifespan, while Ndt1 overexpression resulted in increased mitochondrial and cellular NAD(H) levels and decreased chronological lifespan [192]

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In addition, the circulating pro-inflammatory cytokines (Figure 5E, 5F and 5G, respectively), as well as the chemokine (Figure 5H), were significantly increased in the CCl4-treated mice compared to the sham group